Preparative HPLC for biopharmaceutical

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Preparative High Performance Liquid Chromatography (HPLC) for Biopharmaceuticals: Hipersep® Bio Line

 

Novasep has more than 20 years experience in polishing fragile molecules such as insulin, interferon, EPO, factor VIII.

 

 

Novasep Process has designed, built and sold the largest number of industrial HPLC systems for protein polishing in the world.

 

Typical Applications

Polishing of:

  • Factor VIII
  • Lipids
  • Polysaccharides
   

Hipersep® Bio - Product Line

High Performance Gradient

The mass-flowrate control and the in-line mixing system ensure highest precision (± 0 .1%) of composition of isocratic step and gradients.

Smart Fraction Collection System

the system is based on:

  • time and/or detection threshold and/or slope
  • volume
  • time/volume after an event

Fully Customized Systems

Novasep Process engineers design customized units, ideally suited to your facilities and specific process needs.

Hipersep®

LAB I

LAB II

S

M

L

XL

Productivity range (kg/day)

0.01 - 0.2

0.02 - 0.3

0.1 - 5

0.2 - 20

0.5 - 40

40 - 140

Typical Prochrom® column diameters (mm)

50

80

80

110

150

200

200

450

300

600

600

1200

Flow rate (L/h)

6 - 36

12 - 54

60 - 150

150 - 1000

300 - 2000

500 - 2500

Standard
max operating
pressure (bar)

70

70

70

70

70

70

Number of fractions

* optional

5 to 10 *

5 to 10 *

5 to 10 *

5 to 10 *

5 to 10 *

5 to 10 *

Dimensions
W x H x D (cm)

88 x 123 x 70

88 x 123 x 70

195 x 175 x 100

225 x 195 x 110

225 x 205 x 160

260 x 205 x 170

Average
weight (kg)

300

350

675

1250

1475

2500

Software - Hipersep® SE-Bio

  • PLC controlled with PC user interface
  • multiple safety levels
  • user-friendly, designed for chromatographers and producers
  • validated software compliant with 21 CFR part 11 and GAMP 4

Options

  • injection pump
  • backflush, recycling
  • temperature control
  • additional detectors: pH, conductivity, IR (standard UV detectors)
  • design for ATEX zone
  • automated wiped or falling film evaporators
  • tankfarms and solvent recovery systems
  • others

Novasep Process Biopharma PPD Services

Novasep Process offers complete process development services , and provides performance guarantees for processes supplied.

Benefits and Advantages

Experience

A long track record thanks to more than 20 years experience in polishing insulin, interferon, EPO, factor VIII.

Novasep Process has designed, built and installed the largest number of industrial HPLC systems for protein polishing.

Scalability

HPLC systems incorporate columns from a few millimetres up to 1.6 m internal diameter. Modeling tools allow easy scale-up with similar performance and optimized fluid dynamics.

Expertise

Unique teams of chemists, biochemists, process and computer engineers combine their complementary talents to develop and continuously improve purification processes.

Other

Please challenge us!

 

Browse our biopharmaceutical applications

Download our brochure on preparative HPLC brochure for biopharma

Contacts

Europe: biopharma@novasep.com

USA: biopharma.usa@novasep.com

Japan: japan@novasep.com

Asia: china@novasep.com

Other countries biopharma@novasep.com