Preparative Supercritical Fluid Chromatography (SFC): Supersep® Line

The Supersep™ line is the result of Novasep engineers' knowledge of Supercritical Fluid and High Performance Preparative Liquid Chromatography, combined with innovative technical solutions to handle supercritical fluids to recover efficiently the purified materials and providing a fully automated and safe technology.
 
Supersep™ units are the green technology solution for laboratory scale purification of chiral compounds and complex mixtures, from g/day to 10's of kg campaigns. They are the answer to medicinal and chemical development chemists' look for to purify molecules.

Supersep™ Systems offer Numerous Benefits:

• Time reduction:
  Throughput 3 or 5 times greater than conventional preparative HPLC.
• Delivery:
  Highest recovery ratio of the purified target compound, using patented cyclone separators.
• Multi-task assistant:
  Automatic C.I.P. (Cleaning-in-place) ensures quickest product changeover.
• Green and cost efficient:
  Supersep™ systems include CO₂ recycling technology (patent pending), ensuring lowest installation and operating costs.

Specifications

 

Supersep™	20-30	30-50	50-60	80-100
Productivity (g/day)	5 - 100	10 - 300	100 - 1500	300 - 4000
Colum diameter (mm)	20 - 30	30 - 50	50 - 60	80 - 100
CO2 flow rate (g/min)	50 - 200	70 - 350	200 - 1000	600 - 3000
Co-solvent (ml/min)	0 to 100	0 to 100	0 to 250	0 to 750
Injection flow rate (ml/min)	5 - 24	5 - 24	10 - 100	150 - 250
Max pressure (bar)	250
Operating temperature (°C)	10 - 60		15 - 60
CO2 recycling* *patent pending	standard
Product recovery* *cyclone separators	> 99
Number of fractions	4 to 6
Dimensions WxHxD (cm)	170 x 190 x 80	170 x 190 x 80	161 x 204 x 105	400 x 350 x 200

Supersep™ 30 - 50 unit

  
Supersep™ 50-60 unit

Supersep Max, dedicated to tough separations

In order to increase the productivity of  chiral separations and enhance the yield of difficult separations, Novasep has developped Supersep Max™, an innovative two-column SFC process.

Discover Supersep Max™

Optimum Design: Performance, Reliability and Robustness.

The Supersep™ units are designed to work at elevated pressures (250 bar - 3,600 psi) and temperatures (60°C). Important process control and safety elements are installed on the units such as heat exchangers, pressure regulators, rupture discs, check-valves, etc. In addition, the control software monitors the proper and safe operation at many locations in the flow path.
Polarity of the eluent can be modified by mixing co-solvent with CO₂ , in any proportions. Isocratic elutions, as well as pressure or co-solvent gradients can be programmed in operating recipes.
 
Prochrom® DAC columns:
For optimum performance, specially adapted Prochrom® DAC columns are used to provide efficient, stable and scalable processes. The columns, rated at up to 300 bar (4,350 psi) are designed to prevent damage to the packing material at the high SFC operating pressures. Even fragile media such as some chiral stationary phases made with wide pore silicas can be utilised.

Prochrom® LC50 SFC column

Product Recovery & Eluent Recycling

• An important consideration in the design of a PS-SFC unit is product recovery.
  The SupersepT units are equipped with very efficient patented cyclone separators that allow over 99% of the purified material to be recovered.
   
• CO₂ recycling is also provided as an integral part of the Supersep™ units. The recycled carbon dioxide is cleaned prior to being recycled. Thanks to patented technology, eluent recycling is effective when a modifier is present.

Software

• Fully automated (24 hrs unattended operation)
• PLC controlled, with PC user interface
• User friendly designed for chromatographers and chemists
• Designed for 21 CFR part 11 compliance
• 3 modes of injections:
  • Loop injection
  • Directly on column
  • Directly in CO₂ stream
• Co-solvent gradient
• Pressure gradient

More information on CHROMSOFT®

Hardware

• UV Detector – variable wavelength
• Wetted parts : S.S. 316 L and PTFE
• Equipped with wheels for mobility
• Includes heating and cooling units
• Designed to accept liquid or gas CO₂ supply, thereby minimizing CO₂ supply set up cost.

Multi Level Safety Features

Design	- Individual certificates on all pressure vessels
Mechanical	- All pressure vessels protected by rupture discs
Electronic	- Leak detection - High/low pressure alarms and fail-safe mode - Pump membranes rupture detection

Options

• Explosion proof design
• Full cGMP documentation and IQ/OQ
• On-line polarimeter
• Engineering of custom designed Collection tanks and CO₂ supply systems