Exclusive Synthesis Services: Chemical Route Design

Chemical Routes for Active Molecules.

Novasep offers unique chemical route design services.

Our strength lies in our ability to mix proven and/or innovative chemistry with innovative technologies.

For example, Novasep's team will introduce a preparative chromatography purification at the appropriate step, simplifying and reducing the number of synthesis steps to obtain a pure and economically advantageous API.

Novasep can combine over 20 steps, mixing hazardous chemical reactions to synthesize and purify highly potent active ingredients.

Stages of a Chemical Route Design

The "early stage" in developing a chemical route and setting an "innovative chain process" can be summarized as follows:

• Get a structure,
• Organize a brainstorming session among chemists of our chemical route design team ,
• Identify several routes,
• Rank them according to criteria (confidential)
• Work in parallel on 2-3 alternatives...

Get at least one right alternative!

Technologies for Chemical Routes Design

Novasep's team of experienced chemists and experts design economically advantageous and green synthetic routes to obtain active molecules for customers. To obtain breakthrough pathways, we combine the following technologies:

• Chiral technologies: asymmetric synthesis, chiral pool, preparative chiral chromatography,
• Hazardous chemistry: azide, diazomethane, diborane, ozonolysis, carbonylation,
• Synthesis and purification of HPAIs under OEB 5,
• Multi-step, multi-ton synthesis

Benefits & Advantages

This tool box of process technologies brings solutions that adapt to the maturity stage of the customer's active molecule. Routes can be designed for efficiency, for optimization and according to the required production scale.

For example, one chemical project may require the capacity to scale-up rapidly, whereas a customer having a more mature molecule may be more focused on reducing the manufacturing costs through innovative process.

Embracing the customers' challenges and stakes as our own, our team is committed to design chemical routes with dedication while partnering with the customers' team. Brainstorming on retro-synthetic analysis is one of our team's forte!

This is the right environment which encourages innovative ideas which in turn drives and supports our partners' business objectives.

Novasep endeavours to always conduct itself with the highest level of integrity and professionalism: transparency, and confidentiality. This sense of ethics is building the long-term working relationship with our customers.