Novasep Synthesis Proprietary Products: MAME Reagent

Reagent

MAME
Magnesium methylate
(8 % solution in Methanol)

Formula	C2H6MgO2
Molecular Mass	86.3 g/mol
CAS-No.	[109-88-6]
EINECS	203-715-8
Scale of Development	Commercial

Specification

Appearance	colourless to yellowish liquid
Identity	conforms
Purity
Sum of MgCO3 and Mg(OH)2, calculated as Mg(OH)2	< 0.1 w/w %
Ethanol	< 0.01 w/w % (GC)
Assay
Mg(CH3O)2	7.5 - 8.5 % (Titration)

Transport Information

Transport classification	UN-no.: 1230 Class: 3
Packaging	Steel drums, 200l
Sample Size	50 ml or 1 l
Availability	Samples available

Quality / Regulatory

Non-GMP product. The synthesis of this product can be performed under c-GMP upon request / agreement. Please feel free to ask for more information.

Applications

Used in the synthesis of pharmaceutical products: antiviral (HIV, Hepatitis), antiulcer, gastroesophageal reflux and in the development of oncologic drugs:

• MAME is a milder alkali reagent compared to the corresponding sodium or calcium alkoxides
• a solution, easy to dose
• MAME can eliminate traces of moisture from solvents
• MAME can be used as catalyst for anhydrous reactions were hydrolysis or dehydration potential exists
• MAME can be used as catalyst or co-catalyst in manufacturing polyolefins
• MAME can be used in Meerwein-Pondorf reactions and Methanolysis
• MAME can be used in the alkoxylation of fatty alcohols

Other application areas for MAME are the coating of metal material for electromechanical hardware or the deacidification of paper (conservation of books).

Contact

reagents@novasep.com

Examples

Tishchenko Reaction
The Tishchenko Reaction is a disproportionation reaction that allows the preparation of esters from two equivalents of an aldehyde.

Meerwein-Ponndorf Reaction
The Meerwein-Ponndorf Reaction is the "reduction" of a carbonyl compound with an alcohol.

De-protection with MAME

US 5712300, WO 1997032846, EP 0898562, JP 2000506163

"De-amination" with MAME

EP 0358154, WO 1990005730, JP 1991095165, JP 1995149718, JP 1996301766, JP 1996301765

Keto-enol isomerization