Hazardous Chemistry: We Do What Others Do Not Dare!

Custom Synthesis using Hazardous Reactions

Novasep Synthesis is a global leader in hazardous chemistry, operating facilities in Leverkusen-Schlebusch (near Cologne, Germany) and Finorga (France). It offers custom synthesis services using a unique portfolio of specific hazardous technologies based on either difficult compounds or reactions.

 

Novasep Synthesis has an extensive experience (more than 130 years) through the history of the Leverkusen site (Dynamit Nobel) in the production of hazardous compounds and in the identification of short and elegant synthesis routes using hazardous chemistry.

 

Benefits and Advantages of Hazardous Reactions

The use of hazardous chemistry in chemical synthesis has several advantages:

• generally they are highly efficient reactions,
• the reactions are usually very consistent and generate high yields.
• When applicable, they can be significantly cost-advantageous versus alternative routes.

Novasep offers customers tailor-made solutions using these specific technologies, with its R&D chemists continuously focused on developing and optimizing processes to overcome each customer's unique requirements.

At the same time, the highly explosive nature of the reactions demands extensive know-how, high safety standards, and strict process controls. In Leverkusen, special safety concepts are in place to secure scale-up from lab to industrial scale. The FDA-approved and ISO 9001/14001 certified site produces a variety of registered intermediates and APIs.

Assets of Novasep Synthesis in Hazardous Chemistry

• Expertise:
  Novasep is a leading company in Synthesis technologies and operates the world's largest cGMP Azide facility available for custom synthesis. Novasep masters and operates industrial Diborane and Diazomethane reaction facilities to give you access to C1-chain prolongation, small ring structure and stereoselective reactions.
   
• Innovation:
  Unique teams of chemists and process engineers combine their experience and talents to give you better access to new molecular structures as well as new and cost-effective synthesis routes for your API or advanced intermediates.
   
• Safety:
  Novasep provides supply security: even in Hazardous Chemistry with its unique know-how and its special safety skills, Novasep has proven to master risks, that others do not dare to take. Implementing an Azide, Diazomethane, or a Diborane step in your synthesis is safe if you benefit from Novasep's proven experience.

Hazardous Chemistry Know-How:

• Explosive compounds
• Shock & friction sensitive compounds
• Thermally sensitive compounds
• Very toxic materials
• Highly energetic reactions

Special Safety Skills Required:

• Ability to handle a broad range of sensitive chemicals
• Specific installations & equipment to operate hazardous processes
• Isolated production units
• Extensive safety testing

Project Management at Novasep

Novasep manages projects in close relationship with its customers. Customer intimacy is one of Novasep's forces. Our scientists and chemists are closely involved and are used to adapting to the customer's culture doing things the way customers would do internally.

When Novasep develops a Process for customers, all the information regarding the project is transferred to them; even the "chemist's magic touch" is delivered, described so that learning time is shortened and customers do not have to waste it finding this "magic touch". Transparency culture and scientific ethics, combined with an open communication culture is definitely our special way to manage projects. Understanding stakes is the key to bring an understanding of the project for both sides and to lead it to success.

Novasep's teams are committed to go beyond their customers own expectations. The fact that Novasep is a user and a provider, while embracing its customers' challenges and stakes as its own, provides an environment that encourages innovative ideas. This drives and supports our partners' business objectives. Novasep endeavours to conduct itself with the highest level of integrity and professionalism, transparency and confidentiality. Ethics are an essential part in building long-term working relationships with our customers.

Novasep focuses on nine key technologies:

Azide Chemistry	Borane Chemistry	Hydrazine Chemistry
Ethyl Diazoacetate / Diazomethane Chemistry	Azodicarboxylic Acid Derivatives	Carbon Disulfide Chemistry
Nitroalkane Chemistry	Carbonylation	Ozonolysis

   

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See the applications of hazardous chemistry.

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