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Novasep Technologies for Food Ingredient Manufacturing:

A Unique Palette of Technologies and an Unparalleled Breadth of Key Unit Operations

Novasep Palette of Technologies for your Food Ingredient Production and Purification

Continuous Low Pressure Chromatography for the Purification of Food Ingredients

See our Chromatography technology page.

Click here to discover Applexion® SSMB: Sequential Simulated Moving Bed system
Click here to discover our continuous chromatography system: NS2P

Ion Exchange & Adsorption

The most popular method for the purification of proteins and other charged molecules is ion exchange chromatography.  In cation exchange chromatography, positively charged molecules are attracted to a negatively charged solid phase. Conversely, in anion exchange chromatography, negatively charged molecules are attracted to a positively charged solid phase. To optimize the binding of all charged molecules, the mobile phase is generally a low to medium conductivity (salt concentration) solution. 
The adsorption of the molecules to the solid phase is driven by the ionic interaction between the two moieties and binding capacities are generally quite high. The strength of the interaction is determined by the number and location of the charges on the molecule and solid phase. By increasing the salt concentration (generally a linear salt gradient), the molecules with the weakest ionic interactions are disrupted first and eluted earlier in the salt gradient. Those molecules that have a very strong ionic interaction require a higher salt concentration and elute later in the gradient.


Typical example of ion exchange technology

Membrane Processes

See our Filtration technology page.

Principles of Tangential Flow Filtration (click here to see the animation)
Filtration processes using membranes and Tangential Flow Filtration (TFF) consist of separating dissolved or suspended elements, in relation to their molecular weight cut-off. When creating a pressure difference between retentate and permeate, the membrane acts as a filter. The substances smaller than the membrane pores are combined with the solvent, named permeate, while the larger molecules or particles are retained as retentate.

 

Membranes & Systems

For highly demanding or very large scale applications, we offer Cross-Flow Filtration systems (CFF) from reverse osmosis (RO), nanofiltration, ultrafiltration to microfiltration including reliable mineral Kerasep® membranes.

Evaporation & Crystallization

See our Evaporation & Crystallization technology
Evaporation and crystallization processes and equipment can be configured as multiple effect, thermo-compression and mechanical recompression. They can be fully integrated in our optimized downstream processes.

Catalytic Conversion 

This conversion could be heterogeneous or homogeneous, and enzymatic or chemical.

Novasep Services for your Ingredient Manufacturing Process

We combine the complementary talents of agrochemists and process engineers to offer our expertise in Process Development Services and functional ingredient manufacturing servicessuited to your expectations.

Download our brochures for ingredient purification and production (bulk, food, functional).

For any questions on Novasep's purification/separation services and equipment for industrial biotech applications, please contact us.

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