Novasep Technologies for Functional Ingredient Manufacturing:

A Unique Palette of Technologies and an Unparalleled Breadth of Key Unit Operations

Novasep Palette of Technologies for your Functional Ingredient Production and Purification

Continuous Low Pressure Chromatography for the Purification of Functional Ingredients

See our Chromatography technology page.

Click here to discover our Applexion® SSMB Sequential Simulated Moving Bed system 
Click here to discover our NS2P  continuous chromatography system for binary and ternary separations

Ion Exchange & Adsorption

See our ion exchange technology page
See our adsorption technology page

The most popular method for the purification of proteins, amino acids, organic acids and other charged molecules is ion exchange chromatography.  In cation exchange chromatography, positively charged molecules are attracted to a negatively charged solid support. Conversely, in anion exchange chromatography, negatively charged molecules are attracted to a positively charged solid support. 

To optimize the binding of all charged molecules, the mobile phase is generally a low to medium conductivity (salt concentration) solution. The adsorption of the molecules to the solid support is driven by the ionic interaction between the two moieties and binding capacities are generally quite high. The strength of the interaction is determined by the number and location of the charges on the molecule and solid support. By increasing the salt concentration (generally a linear salt gradient), the molecules with the weakest ionic interactions are disrupted first and elute earlier in the salt gradient.

Those molecules that have a very strong ionic interaction require a higher salt concentration and elute later in the gradient.

Typical example of ion exchange technology

Click here to discover our Applexion® NRS Process forthin juice deliming / softening.

Membrane Processes

See our Filtration technology page.

Principles of Cross-Flow Filtration (click here to see the animation)

Filtration processes using membranes and Cross-Flow Filtration (CFF) consist of separating dissolved or suspended elements, in relation to their molecular weight cut-off. When creating a pressure difference between retentate and permeate, the membrane acts as a filter.

The substances smaller than the membrane pores are combined with the solvent, named permeate, while the larger molecules or particles are retained as retentate.

Membranes & Systems

For highly demanding or very large scale applications, we offer Cross-Flow Filtration systems (CFF) from ultrafiltration to microfiltration including reliable mineral Kerasep® membranes.

Click here to discover our Kerasep® mineral membranes

Click here  to discover our Cross-Flow Filtration (CFF) modules and systems

Evaporation & Crystallization

See our Evaporation and  Crystallization technology pages.

Evaporation and crystallization equipment can be configured as multiple-effect, thermo-compression and mechanical recompression. They can be fully integrated in processes developed by Novasep.

Click here to discover our evaporation and crystallization systems.

Catalytic Conversion 

This conversion could be heterogenous or homogeneous, enzymatic or chemical.

Novasep Services for your Ingredients Manufacturing Process

We combine the complementary talents of agrochemists and process engineers to offer our expertise in Process Development Services and Functional Ingredients Manufacturing Services suited to your expectations.

Download our brochures for ingredient purification and production (bulk, food, functional).

For any questions on Novasep's purification/separation services and equipment for industrial biotech applications, please contact us.