Novasep pioneered preparative supercritical fluid chromatography (SFC) in the 1980’s. In a recent past, this technology has gained acceptance in the life sciences industry, due to its intrinsic performance and environmentally friendly nature.
The fastest delivery of your molecule. Our Supersep SFC systems enable the rapid purification of grams to kilograms for your compounds, and speed up the availability of your pure products for medicinal chemistry up to clinical trials. The unique automatic cleaning-in-place feature enables the fastest product changeover.
Benefit from our team of experts! Our technologies are continuously improved through consistent customer feedback as well as the expertise of our own custom purification teams.
The unique CO2 recycling technology of
Prochrom® Supersep systems provides dramatic reduction of solvents and CO2 consumption. The integration of CO2 delivery and contained fraction collection systems guarantee the lowest global investment costs and the safest operation at any scale.
Prochrom® Supersep systems enable fast, robust, environmentally friendly and efficient purifications from grams to kilograms, and up to tons for specific applications. Our SFC equipment incorporates a robust, industrial design with high performance features such as DAC (Dynamic Axial Compression) columns.
Supercritical fluid chromatography is:
For more information about SFC and when to use it, please see our chromatography technologies page.
We develop SFC systems ranging from lab to industrial scale but SFC best suits medicinal chemistry and early development phase, for separation of non-polar compounds, from grams up to tens of kilograms.
|Typical sample/batch size (g)||1 – 50||10 - 500||100 – 10,000||5,000 – 100,000|
|Prochrom® column diameter (mm)||20 – 30||30 - 50||50 - 60||80 - 100|
|CO2 flowrate (g/min)||30 - 200||70 - 350||200 - 1000||600 - 3000|
|Co-solvent flowrate (mL/min)||0 – 100||0 – 100||0 – 400||0 – 1000|
CO2 recycling after solute separation is standard design for preparative SFC systems. If not, CO2 consumption would easily exceed 10 or even 20 kg of liquefied gas per hour for a preparative SFC system equipped with a 50 mm I.D. column!
Therefore, all of our Prochrom® Supersep systems are equipped with a robust and efficient CO2 recycling device that reduces the required quantities of fresh CO2 by 10 to 20 times.
For more information about the economic interest of CO2 recycling, please download our white paper. “Recycling of CO2 on a Supercritical Fluid Chromatography (SFC) Pilot Unit”.
Discover our offering for APIs:
Download our brochures for API synthesis and purification.
Contact us for any API and advanced intermediates production request.