Novasep
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Custom Purification Facilities

Our unrivalled array of chromatography units to serve your purification needs

Novasep offers the broadest range of preparative chromatography systems from lab to production scale of any custom manufacturer.

We operate large scale chromatography on multiple sites, from gram to multi-ton scale, from batch chromatography (HPLC, SFC) to continuous chromatography (Prochrom® Varicol and SMB).

We will use the chromatography process that is best suited for your project and for your constraints, whether it is time or production cost.  To further meet your constraints, this purification process can be combined with synthesis steps to be performed at the same site instead of managing logistics between two different sites.

 

Integrated capabilities for green and cost-effective purification

Novasep has unique chromatographic capabilities throughout 6 R&D facilities worldwide (4 in France, 1 in the USA and 1 in China) and 4 FDA inspected production sites equipped with large-scale chromatography systems.

All facilities include solvent recycling and drying capabilities for “green” and cost-effective separations (up to 99% of the solvent can be recovered).

Separations can be done in a cGMP or non-cGMP environment, depending on your needs or in a confined area for HPAI purifications.

Development / Kilo Lab

Technology Equipment Key Benefits
Preparative HPLC
  • 10 Prochrom® Hipersep -Lab equipped with Prochrom® DAC (Dynamic Axial Compression) columns from 50 to 150 mm I.D.
Ideal for complex mixtures and HPAIs
Multi-Column Continuous Chromatography
  • 2 Prochrom®  micro-Varicol equipped with 10 mm I.D. column
  • 3 Prochrom®  Varicol integrated columns from 25 to 50 mm I.D.
  • 2 Prochrom®  Varicol equipped with 80 mm I.D. column
Robust process, ideal for scaling up chiral separations.
Highest recovery yields
Preparative SFC
  • 2 Prochrom®  Supersep  equipped with columns from 20 to 50 mm I.D. (non cGMP)
Cost-effective solutions with integrated CO2 recycling
Rapid access to pre-clinical quantities

Clinical supply and commercial production:

Technology Equipment Expertise
Process-Scale HPLC
  • 5 Prochrom®  Hipersep equipped with Prochrom DAC columns from 200 to 800 mm I.D.
Ideal for complex mixtures and HPAIs
Cost-effective solutions with integrated solvent recycling
Multi-Column Continuous Chromatography
  • 4 Prochrom®  Varicol equipped with Prochrom® DAC columns from 200 to 600 mm I.D.
The most cost-effective solutions for chiral separation up to 100's tons per year

For more information about our sites equipped with chromatography technologies, follow the links below:

Download our brochures for custom manufacturing services

For any questions on Novasep's synthesis and purification offering, please contact us.

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