Chiral Technologies: Asymmetric Synthesis

Asymmetric Synthesis

Asymmetric synthesis consists in creating a stereocenter by asymmetric induction. The creation of this chiral center is made possible thanks to a chiral catalyst, auxiliary or substrate that will bind (covalently or not) the molecule. Thus, a reagent will attack for example the less hindered face, leading to the formation of an enantiomerically pure compound.

We have extensive experience in stereoselective synthesis using both diastereoselective and enantioselective synthesis at very large scale and our R&D scientists always keep themselves informed about the latest development in asymmetric synthesis, in order to identify the best synthetic route yielding pure enantiomers.

The key stereoselective reactions we master include:

Asymmetric catalysis

Stoechiometric enantioselective synthesis

Diastereoselective synthesis (including chiral auxiliary chemistry)

Asymmetric organocatalysis

Enzymatic asymmetric synthesis

Metal-catalyzed asymmetric synthesis

Our expertise and capacities in cryogenic reactions, biocatalysis, organometallic catalysis and hydrogenation are clearly very strong assets to successfully conducting stereoselective reactions.

Example of asymmetric synthesis using a chiral auxiliary:

Example of asymmetric synthesis using a chiral catalyst:

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