Examples of APIs produced by chiral chromatography

Armodafinil

Nuvigil®

Narcolepsy, Jet lag disorder, obstructive sleep apnea and shift work sleep disorder

Cephalon

Marketed
in 2009

-

Large-scale chiral chromatography has been used to significantly reduce the time to market and produce launch quantities
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Escitalopram

Lexapro®

Depression, generalized anxiety disorder

Lundbeck

Marketed
in 2002

$1.24
billion

Currently produced by industrial chiral chromatography

Levitiracetam

Keppra®

Epilepsy

UCB

Marketed
in 1999

$1.75
billion

Currently produced by large-scale chiral chromatography
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Radafaxine

-

Restless leg syndrome, depression

GlaxoSmithKline

Discontinued

-

Thanks to the use of chiral chromatography for Radafaxine production, GSK was awarded twice for green chemistry
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AMG221

-

Type 2 diabetes

Amgen

Phase I

-

The shorter reaction
sequence and efficiency of the chromatographic separation make this route a more attractive option for long-term applications
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Pagoclone

-

Persistent developmental stuttering

Indevus Pharmaceuticals

Phase III

-

Chiral chromatography appeared to be the most time-efficient and cost-effective method in development
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