Which Equipment for Large-scale Chiral Chromatography?

Novasep's unmatched offering in chromatography will provide you the most adapted solutions for your chiral resolutions. We understand your needs and we will assist you in making the appropriate choice.

For your Early Development: the fastest Delivery

For your late Development and Production: the lowest Cost

 

For your early development: the fastest delivery

At early development stage, you need methods to rapidly and securely prepare grams to kilograms of your candidates, ready for the next clinical phase. With their low impact on the environment, low cost preparation and easy operation, our versatile equipment will be used by your process chemists for every chiral compound in your portfolio.

 

For these reasons, Novasep recommends, our Supersep™line of supercritical fluid chromatography systems.

 

 

Supersep® 20-30

 

 

Specially designed to separate enantiomers or diastereoisomers from a few grams to kilograms, Supersep™ systems perfectly match your needs for pre-clinical and phase I trials. These systems are in daily use at pharmaceutical development laboratories around the world.

Our Supersep™ units are environmentally friendly thanks to the use of supercritical CO₂ as a mobile phase and with our CO₂ recycling technology (patent pending). They provide a drastic reduction in mobile phase consumption and lower operation costs. Supersep™ will allow you to quickly resolve your racemic mixture with small amounts of co-solvent. You will therefore be able to meet your challenging timelines with the greenest laboratory scale chromatography process, at very high yield and optical purity. Supersep™ systems eliminate your major laboratory productivity bottleneck, allowing you to produce larger amount of compounds with less organic solvents.

Need to prepare larger quantities? Add the Supersep MAX™ Dual-Column option to your Supersep™. This unique proprietary process will dramatically boost the productivity of Supersep™ systems' for 10's of kilograms campaigns.

Looking for the most versatile technology? Hipersep® family of high performance liquid chromatography systems are best associated with our Prochrom® DAC columns to maximize your production of enantiomers in scales from grams to 10's of kilograms.

 

For your late development and production: the lowest cost

For late development and production, you need a cost effective, robust and environmentally friendly route. High optical purity, yield and productivity are a prerequisite. You also need versatile and flexible equipment able to scale-up or down in production to adjust to market demand.

Varicol® is the optimal equipment for your industrial-scale chiral chromatography. A new process derived from the Simulated Moving Bed technology, Varicol® is the state-of-the-art in a continuous process for the separation of binary mixtures. Efficient and integrated solvent recovery and recycling concur to lower operational costs and minimize solvent consumption.

 

Varicol® 6 x 1000 mm

Designed to be an integrated continuous operation, Varicol® systems include an eluent evaporation unit with automated solvent recycling capability along with a dedicated product dryer. When you get to commercial scale, your dry racemic mixture is fed into the systems and purified enantiomer is removed from the dryer.

Simplified scheme of the single unit operation comprising Varicol®,
evaporation system and solvent recycling apparatus

Alternately our Hipersep® units equipped with Cyclojet® steady-state recycling option are perfectly adapted to the separation of enantiomers up to 100's of kilograms.