Groupe Novasep > Technologies > Chiral technologies

What are the examples of large-scale chiral chromatography applied to the synthesis of APIs?

There are many examples of the use of large-scale chiral chromatography to produce chiral APIs. Widely used in early development programs to rapidly prepare pure enantiomers for clinical programs. This technique is also well established for full development and commercial production of APIs. Some examples of APIs produced using chiral chromatography are shown in the table below.

Compound Name	Drug Name	Indication	Company	Phase	2006 World. Sales	Comments
*Armodafinil*	Nuvigil®	Narcolepsy, obstructive sleep apnea and shift work sleep disorder	Cephalon	Approved in 2007	-	Large-scale chiral chromatography has been used to significantly reduce the time to market and produce launch quantities
*Escitalopram*	Lexapro®	Depression, generalized anxiety disorder	Lundbeck	Marketed in 2002	$2.75 billion	Currently produced by large-scale chiral chromatography
*Levitiracetam*	Keppra®	Epilepsy	UCB	Marketed in 1999	$1.04 billion	Currently produced by large-scale chiral chromatography
*Radafaxine*	-	Restless leg syndrome, depression	GlaxoSmithKline	Dis-continued	-	Thanks to the use of chiral chromatography for Radafaxine production, GSK was awarded twice for green chemistry
*Pagoclone*	-	Persistent developmental stuttering	Indevus Pharmaceuticals	Phase III	-	Large-scale chiral chromatography was used to reduce time to market and cost of production

Large scale chiral chromatography examples

Groupe Novasep > Technologies > Chiral technologies

What are the examples of large-scale chiral chromatography applied to the synthesis of APIs?