Chiral Chromatography

What's New in Large-scale Chiral Chromatography?

Chiral chromatography has entered into a new era. Industrial chromatography is performed on automated, proven equipment, combining speed, robustness, cost-efficiency and manufacturing versatility. Over the past few years, large-scale chiral chromatography has become an essential tool for the pharmaceutical industry.

Early adopters have significantly reduced their time to market and have brought APIs to 100 multi-ton scale using cost efficient commercial chromatography processes.

mid-1950s Photo courtesy of the FDA History Office

Nowadays

Left: A chemist is shown using a preparative column chromatographic apparatus in the mid-1950s.
Right: A contemporary continuous chromatography Varicol® 6 x 200 mm system used for a chiral resolution.

As pioneers in continuous chromatography, Novasep is recognized as the world leader in preparative and large-scale chiral chromatography. We combine our experience in designing and operating industrial chiral chromatography processes and technologies with our know-how in developing and scaling up challenging organic synthesis, to bring the most cost-efficient global chiral synthesis to reality. Novasep is an ideal partner for your chiral resolutions.

Depending on your needs, we can either rapidly develop an optimized process and use our own chromatography facilities to speed your product to market, or we can build a versatile chromatography unit to install at your own site.

Novasep and Daicel/Chiral Technologies signed an agreement combining our expertise in process development and their expertise in chiral stationary phases. This cooperation ensures that your process is optimally developed for guaranteed performance.

For more information on chromatography at industrial scale and for examples of commercial production including chromatographic purification, view our webinar: "Combining chromatography with smart synthesis for cost-effective production of chiral chemicals".

Download our brochures for synthetic molecule manufacturing.

Contact us  for any synthetic molecule manufacturing request.