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Advanced organic synthesis

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Novasep has the capabilities and experience for multi-step synthesis and purification from hundreds of grams to thousands of tons. We have a unique know-how for conducting certain demanding reactions used in organic synthesis that yield pure organic compounds in a cost-effective and time efficient manner:

Found you target reactions? Learn more about our CMO services for pharmaceutical API, HPAPI, agrochemicals and fine chemicals manufacturing

Cryogenic reactions

We pioneered low temperature reactions at industrial scale for more than 30 years and are equipped for -80 °C reactions at industrial scale.

Ideal to improve selectivity or to use highly reactive compounds such has organolithium reagents, we have can perform cryogenic reactions at pilot-scale (up to 700L) and at industrial-scale (up to 6,000L). We also developed a unique set of two large-scale reactors (3,000 L and 4,000 L) in series for coupling two low temperature reactions.

  • This expertise enables us to easily perform and scale up the following reactions:
  • Halogen-metal exchange (e.g. Li)
  • Li, Na metal reduction
  • Selective deprotonation and subsequent stereoselective / regioselective/ chemoselective reactions
  • Stereoselective / regioselective/ chemoselective reductions (e.g. ketones, imines, esters)
  • Asymmetric reactions (e.g. Michael addition)
  • Selective Friedel-Crafts acylation (e.g. with oxalylchloride)

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Friedel-Crafts reactions

We have the world’s largest cGMP capacity for Friedel-Crafts acylation, alkylation and hydroalkylation with a 6,000 L reactor and more than 30 tons of AlCl3 storage.

We reduce the environmental impact of Friedel-Crafts reactions by supplying the aluminum hydroxide by-product that we generate to water treatment companies.

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Micro-reaction technology

We are highly active in developing reactions based on micro-reactor technology, especially for energetic or safety critical reactions such as glycerine nitration.

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Transition metal-catalyzed reactions

We master catalyzed C-C and C-N cross coupling reactions such as Suzuki, Heck, Sonogashira, and Buchwald reactions from pilot to industrial scale.

Our ability to prepare aryl and vinyl triflates, chlorides and bromides as well as boronic acid derivatives in-house, gives us access to a wide selection of substrates at low cost for transition metal-catalyzed cross coupling reactions.

Novasep CMO Transition Metal Catalyzed Reactions

In addition, our ability to handle carbon monoxide from gram to hundreds of kilogram scale gives us access to a Pd-catalyzed carbonylation reactions.

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Hydrogenation reactions

We are equipped with large-scale hydrogenation capabilities that can be used in both asymmetric and standard version, combined with H-cube screening technology in order to quickly identify the best hydrogenation conditions.

Our production capabilities include 2 x 1,500 L; 3,000 L; 2 x 6,000 L and 8,000 L reactors for hydrogenation reactions at up to 20 bar.

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Halogenation reactions

We are equipped with extensive capabilities for bromination and chlorination reactions. We can use up to 10 MT of bromine in our 6,000 L and 4,000 L dedicated reaction vessel.

We are also experts in using Cl2, PCl5, POCl3 and SOCl2 to produce tons of chlorinated compounds in our 4,000 L vessel dedicated to chlorination reactions.

Thanks to these large-scale capabilities, we manufacture various organic halides that can be used as starting material for the other key reactions we master, such as organometallic chemistry, transition metal-catalysed reactions, etc.

 Novasep CMO Halogenation Reaction

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Organometallic chemistry

We have extensive experience in producing and using several organometallic compounds from kilogram to multi-ton scale.

Our ability to handle diborane from kilogram to multi-ton scale gives us access to several organoboranes (including chiral organoboranes), that can be used in many reactions. More information on organoborane chemistry.

Thanks to our know-how and capabilities in cryogenic reactions, we are able to manufacture large amounts of organolithium reagents.

Our expertise also includes the manufacture of organomagnesium, organotitanium and organosilicon compounds.

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Heterocyclic chemistry

Thanks to our know-how and capabilities in hydrazine, azide, diazomethane and carbon disulfide chemistry, we are able to manufacture, at very large scale, a broad range of nitrogen- and sulfur-containing heterocycles such as pyrazoles, triazoles, thiadiazoles, pyridazines, tetrazoles, aziridines, etc.

Novasep CMO Heterocyclic Chemistry

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Mitsunobu reactions

Mitsunobu reactions are very useful synthetic routes for transforming primary and secondary alcohols into a variety of functional groups with an inversion of configuration. At Novasep, we are able to perform Mitsunobu reactions at a very low cost, thanks to our mastery of hydrazine chemistry to produce azodicarboxylic acid derivatives in house in ton quantities.

Novasep CMO Mitsunobu Reactions Intermolecular Intramolecular Dehydratation 

The most common Mitsunobu reagents are Diethylazocarboxylate (DEAD) and Diisopropylazodicarboxylate (DIAD), but several other azodicarboxylic acid derivatives have been developed as alternatives to DEAD and DIAD and are also produced by Novasep such as DBAD, ADDP, TMAP and TIPA.

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Chemoenzymatic reactions

We have developed in-depth knowledge about biocatalysis and this technique is fully integrated into our chiral toolbox and advanced organic synthesis offering for large-scale regioselective and stereoselective reactions.

We have the experience and capabilities to perform most chemoenzymatic processes from pilot to commercial scale including:

  • Enzymatic resolution
  • Enzymatic asymmetric synthesis
  • Aldol reaction, bio-oxidation, transamination and transesterification

Novasep CMO Enzymatic Resolution Enantiomer

Novasep CMO Asymmetric Biosynthesis

We have recently invested in a new pilot/industrial suite dedicated to enzymatic reactions that includes a 4000 L reactor for the biocatalysis itself, two additional 4000 L work-up reactors, followed by membrane filtration and chromatography units

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More organic synthesis reactions

Going further, we are able to perform many other organic synthesis reactions up to large-scale. These reactions include:

A

Acetylation

Acylation

Acyl chloride chemistry

Alcoholysis

Aldol Additions / Condensations

Alkylation

Amination

Amidation

Arylation

Asymmetric synthesis

Azide Chemistry

B

Bayer-Villiger oxidation

Benzoylation

Biocatalysis

Borane Chemistry

Bromination

Buchwald reactions

C

Carbon Disulfide Chemistry

Carbonylation

Catalyzed C-C, C-N cross coupling

Chlorination

Claisen condensation

Condensation

Curtius Rearrangement

Cryogenic reactions

Cyanation

Cyclisation

Cyclopropanation

D

Dehydrogenation

Dehydrohalogenation

Dehydration

Decarboxylation

Diels Alder reaction

Dynamic kinetic resolution

E

Electrophilic subsititution

Epoxidation

Esterification

Etherification

Ethyl Diazoacetate Chemistry

F

Friedel-Crafts Reactions

G

Grignard reactions

H

Halide Exchange

Halogenation

Heterocyclic Chemistry

Hofmann rearrangement

Hydrazine Chemistry

Hydrogenation

Hydrolysis

Hydroxylation

I

Indole Synthesis via Azide Route

Isocyanates chemistry

Isomerisation

K

Knoevenagel reaction

L

Lithiation (BuLi, LDA, etc.)

Low temperature reaction

M

Mannich reaction

Meerwein Chlorosulphonation

Methylation by Diazomethane

Michael Addition

Mitsunobu Reaction

N

Nitration

Nitroalkane Chemistry

Nucleophilic substitution

O

Organometallic reactions

Oxidation

Ozonolysis

P

Peroxidation

Phosphorylation

R

Rearrangements

Reduction

Reductions with Metal Hydride (LiAlH4, NaBH4, etc.)

Ritter Reaction

S

Sandmeyer reaction

Schmidt Rearrangement

Schotten-Baumann reactions

Sodium Amide Reactions

Saponification

Silylation

Sulfonation

Sulfoxidation

Swern Oxidation

T

Thiolation

Tosylation

W

Wittig reactions

 

Please contact us for any request!

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Downloads
  • Low temperature chemistry
    Low temperature chemistry
    size: 209.2K
    date: 08/12/2014
  • Smart synthesis & advanced purification
    Smart synthesis & advanced purification
    size: 244.3K
    date: 08/12/2014
  • Hazardous chemistry
    Hazardous chemistry
    size: 210.1K
    date: 08/12/2014
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