Hazardous Chemistry: Carbonylation

Large-scale carbonylation reactions using carbon monoxide

We use gaseous carbon monoxide (at up to 10 bar) in palladium-catalyzed reactions for the carbonylation of aryl halides to produce esters, amides, ketones or aldehydes at hundred kilo scale per batch.

Use of carbon monoxide for the carbonylation of aryl halides in aryl esters is a shortcut route compared to a standard 3-step synthesis via a Grignard reagent formation. In addition, carbonylation is a much more versatile than organomagnesium chemistry since it is much more permissive in terms of functional groups.

For more information about carbonylation reactions using carbon monoxide, have look at our white paper on carbonylation, click here.

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