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Hazardous chemistry: carbonylation with carbon monoxide

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We use gaseous carbon monoxide (at up to 10 bar) in palladium-catalyzed reactions for the carbonylation of aryl halides to produce esters, amides, ketones or aldehydes at hundred kilo scale per batch.

 Novasep CMO Carbonylation

Use of carbon monoxide for the carbonylation of aryl halides in aryl esters is a shortcut route compared to a standard 3-step synthesis via a Grignard reagent formation. In addition, carbonylation is a much more versatile than organomagnesium chemistry since it is much more permissive in terms of functional groups.

Novasep CMO Alkoxycarbonylation

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  • Hazardous chemistry
    Hazardous chemistry
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    date: 08/12/2014
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