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Home / Equipment Solutions / LPLC skids and columns / BioSC™ Pilot, from chromatography to Downstream Process skid for biologics

BioSC™ Pilot, from chromatography to Downstream Process skid for biologics

 BioSC Pilot continuous chromatography skid

The winning combination for your biologics purification

BioSC™ Pilot is a chromatography skid for the purification of biologics (such as monoclonal antibodies (mAbs), recombinant proteins, blood factors...), from early pilot phase to small commercial production.

Depending on molecule properties (size, charge, hydrophobicity, biorecognition), our product ranges allow for several purification techniques:

  • Reverse Phase Chromatography (RP HPLC),
  • Normal Phase Chromatography (NP HPLC),
  • Hydrophobic Interaction Chromatography (HIC),
  • Ion Exchange Chromatography (Anion and Cation) (IEX),
  • Size Exclusion Chromatography (SEC),
  • Affinity Chromatography (AC).

The system has been designed to overcome your biomolecules production challenges:

  • Continuous and intensified process thanks to multi-step chaining
  • Product quality: automated and closed system to prevent contaminations and nonconformities
  • Highly flexible: configurable and modular to fit your downstream process


Batch and multiple multi-column processes

BioSC™ Pilot can operate simultaneously and continuously three chromatography separations, including viral inactivation and in-line buffer preparation

BioSC Pilot Processes

The chaining of multiple processes (MS-MCC / Multi-step Multi-Column Chromatography) results in a streamlined and intensified process.

Download the Process intensification white paper

Integrated Viral Inactivation

The patented BioSC™ Pilot Viral Inactivation integrated feature enables full automation and integration of the VI, as well as chromatography process management with a single skid.

BioSC™ Pilot can work

  • in static mode with a 100% tank-based and fully automated process;
  • in dynamic and faster mode with inline acidification (with pH acidification occurring during the liquid transfer).

All parameters are monitored and controlled by the same software.

In-line buffer preparation

Buffer preparation often causes bottlenecks in biopharmaceuticals manufacturing operations as it requires space, time, and resources. To make this stage more efficient, we included an exclusive in-line buffer preparation feature in our BioSC™ Pilot system.

This unique and powerful functionality automatically prepares solutions with the right combination of pH, conductivity and concentration from mother solutions. These three parameters are continuously monitored and controlled by a dedicated algorithm to guarantee accuracy and fast response.


BioSC™ Predict, exclusive simulation and optimization software

Predict is an exclusive simulation and optimization software for the development of intensified chromatography processes for biopharmaceutical purification.

Combining this process characterization method with the BioSC™ Predict software, users can switch from batch chromatography to a streamlined continuous chromatography process, ready to be tested with BioSC™ Lab and BioSC™ Pilot. 

Download BioSC™ Predict


Related Documents


Brochure Icon Insulin Purification Download

Application note

Brochure Icon Elemental packing, simplified packing operation without compromising your performance Download
Brochure Icon BioSC™ Pilot designed for effective and consistent chemical and microbiological cleaning Download

White paper

Brochure Icon Process Intensification and Continuous Bioprocessing by Novasep Download


Video Chromatography intensification strategies using multi-column process Watch now
Video BioSC™ Pilot & BioSC™ Lab technologies Watch now
Video Turnkey solution for continuous downstream bioprocess Watch now
Video Control Strategy in a Continuous and Intensified Bioprocessing Watch now
Video Process development using simulation software for Multi-Column Chromatography Watch now
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