Bio-based chemicals are gaining interest as alternatives or additional sources of chemicals. Among them,organic acids are promising as building blocks and chemical platforms. To integrate the chemical industry supply chain, bio-based products must become commodity products and meet current specifications applied to petro-based chemicals in terms of quality and purity. This article will illustrate several purification challenges that manufacturers encounter by describing an industrial manufacturing process for citric acid production from fermentation to purification.
Each step will be reviewed and explained with special emphasis on the continuous chromatography step based on acid retardation since it is the core operation unit of the described purification process.