Continuous processing is gaining interest in biopharmaceutical industry due to traditional justifications (such as higher productivity and lower costs) as well as its ability to address biopharmaceutical specificities. Continuous chromatography has been in use since the 1960s and has progressed across industries by capitalising on its previous applications, leading each time to major innovations. The successful implementation of continuous chromatography in the pharmaceutical industry in the 90s for the purification of small molecule APIs demonstrated the importance of technological expertise and mastery of regulatory aspects. As a result, several commercial processes have been approved and the technology remains an industrial standard. Biopharmaceutical industry is about to experience the same evolution. To succeed, proven understanding and experience in implementing continuous chromatography at an industrial scale will be key factors.