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Use of Large-Scale Chromatography in the Preparation of Armodafinil

23 May 2008

Armodafinil, the (R)-enantiomer of modafinil, is a medication used to treat the excessive sleepiness associated with narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep disorder. We report here the chemical development of armodafinil and the investigations that led to a commercial route to prepare this pure enantiomer. Three synthetic approaches were used to provide the chiral sulfoxide.

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Conference at Chirality 2008 july 6-9th Geneva

Authors: Hauck W., Adam P., Bobier C., Landmesser N.


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