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Viral vector manufacturing: a global and integrated offer to support your projects
Biopharmaceuticals

Viral vector manufacturing: a global and integrated offer to support your projects

Viral Vector Manufacturing Novasep Banner

Viral vectors can contribute to transform the lives of patients with severe diseases. Novasep, as a reliable CDMO, is committed and proud to be part of this rewarding challenge by offering its support to the clinical & commercial manufacture of your viral vectors.

A strong track record in viral vector manufacturing

For 20 years, Novasep has acquired experience in the development and manufacturing of biomolecules. Novasep’s specific know-how in a wide range of viral vectors includes:

… For gene therapy, immunotherapy, vaccination and other therapies.

More than 100 cGMP viral vector batches have been produced and released by Novasep over the last 5 years:

Type

Track record & case studies

Adeno-associated virus (AAV) vectors
Download the AAV leaflet with our detailed track record & case studies!
Adenovirus vectors
Download the Adenovirus leaflet with our detailed track record & case studies!
Lentiviral vectors
Download the Lentivirus leaflet with our detailed track record & case studies!
Other types of viral vectors such as HSV, VSV, VEEV…
Download the HSV, VSV, VEEV vectors leaflet with our detailed track record & case studies!

Our viral vector manufacturing solutions

Novasep offers a global and integrated solution for viral vector manufacturing, including:

  • Process transfer, development, optimization, scale-up and validation
  • Assays transfer, development and validation
  • Small to large scale manufacturing
  • Upstream, downstream and aseptic Fill & Finish
  • Pre-clinical, clinical and commercial applications

Production services for your viral vectors

Our viral vector production services include upstream processing and downstream processing:

- Upstream processing (USP)

Adherent mode

  • Disposable support CS10/HS36
  • Fixed-bed bioreactors (e.g.: iCELLis®)
  • Microcarriers in bioreactors

 Suspension mode

  • Batch, fed-batch & perfusion
  • Disposable technology
  • Scalable up to 2 000L

 - Downstream processing (DSP)

  • Large set of purification technologies; chromatography, TFF, filtration…
  • Scalable up to 2 000L

Novasep Viral Vector Industrialization Process

Click on this infographic to learn more about  
our viral vector commercial manufacturing offer

Fill & Finish services for your viral vectors

Novasep also has a fully dedicated plant for Fill & Finish (F&F) offering flexibility for standard & custom services. Our dedicated team can also provide stand-alone services.

  • Manual or automatic liquid filling machine
  • Hundreds to 4 000 vials per session
  • Customizable (volume, stoppers, vials)
  • 2mL to 100mL vials
  • Filled volume: 0.25mL to 100mL

 The drug product release is handled by a Qualified Person at Novasep.

Watch the video below to learn more about our viral offer:

 

Our 2 sites in Belgium for viral vector manufacturing

Our 2 viral vector manufacturing sites are ideally located at the heart of the Belgium’s largest biotech hub.

- Gosselies’s site is dedicated to clinical viral vector production:

  • Process & analytical development
  • cGMP: Upstream processing (USP) and Downstream processing (DSP)
  • Small to Mid-scale: up to 200L

- Seneffe’s site is dedicated to clinical and commercial viral vector production:

  • cGMP: Upstream processing (USP), Downstream processing (DSP) and Fill & Finish (F&F)
  • QC labs
  • Mid to Large scale: up to 2 000L

Senrise-IV, a new commercial production facility for viral vectors

Novasep Senrise IV Commercial Production Facility For Viral Vectors

Inaugurated at the beginning of October 2018, Senrise-IV is dedicated to the commercial manufacture of your viral vectors:

  • 2 cGMP manufacturing lines
  • Suspension and / or adherent modes
  • Up to 2 000L scale
  • Commissioning in Q1 2019
  • Located in Seneffe, Belgium

Watch the video below to learn more about our Senrise-IV commercial production facility:

Senefill, our new commercial Fill & Finish facility

To support your project’s success, Novasep has invested in a new commercial facility for aseptic Fill & Finish (F&F) operations: Senefill.

  • A full state-of-the-art facility
  • Fully automatic filling under isolator
  • Up to 10,000 vials per session
  • Filling of viral vectors, plasmids and other biologics (mAbs, proteins…) including stand-alone services
  • Commissioning in H2 2019
  • Located in Seneffe, Belgium

Watch the video below to learn more about Senefill, our new commercial facility for aseptic Fill & Finish operations and discover our complete supply chain for drug products manufacturing:

Our viral vector manufacturing capabilities

Novasep has a wide range of capabilities adapted to viral vector manufacturing. To learn more about our capabilities, download our viral vectors brochure!

Novasep Viral Vector Manufacturing Capabilities

 

Downloads
  • Fill and Finish services for small volume biologics
    Fill and Finish services for small volume biologics
    Aseptic filling is a critical step in the manufacturing of biopharmaceuticals products: discover our...
    Download +
  • Other types of Viral Vectors (such as HSV)
    Other types of Viral Vectors (such as HSV)
    Discover an exclusive case study about Herpes Simplex Virus (HSV) manufacturing for cancer immunothe...
    Download +
  • Adenovirus Vectors: finding the good in everyone
    Adenovirus Vectors: finding the good in everyone
    Learn more about Adenovirus Vectors and discover an exclusive case study about the manufacture of an...
    Download +
  • Lentivirus Vectors: finding the good in everyone
    Lentivirus Vectors: finding the good in everyone
    Learn more about Lentivirus Vectors and discover an exclusive case study about Lentivectors manufact...
    Download +
  • AAV Vectors: finding the good in everyone
    AAV Vectors: finding the good in everyone
    Learn more about AAV Vectors and discover an exclusive case study about the manufacture of an AAV2 v...
    Download +
  • Viral Vectors: finding the good in everyone
    Viral Vectors: finding the good in everyone
    Novasep is a reliable partner to support your clinical and commercial manufacture of viral vectors
    Download +
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