Whether it is yeast or bacteria-based production, insulin manufacturing processes always imply 2 or 3 orthogonal chromatography steps.
Novasep has been providing industrial purification solutions and specialized process development services to major insulin manufacturers worldwide for decades now. We offer a full range of HPLC and LPLC equipment to equip any best-in-class downstream purification workshop.
As the world leader in chromatography technologies, Novasep also proposes BioSC™, an innovative technology to further reduce production costs.
WORLD LEADING PROCHROM HPLC TECHNOLOGY FOR THE POLISHING STEP
The Prochrom® HPLC range is recognized worldwide as a reference in the industry for the polishing of insulin. As a testament to our reputation, we supplied the world’s largest HPLC column dedicated to insulin purification.
Designed for smart industrial operations, the robustness and performance of the Prochrom® systems have made them trusted and durable chromatography solutions for insulin manufacturing.
Fully automated, the Prochrom® technology allows reproducible industrial operations.
Thanks to the DAC technology, performance of the separation is maintained over time, always delivering high insulin purity and yield.
Your column is easily maintained and cleaned thanks to a clever top-down piston technology.
PROCHROM®-BIO LPLC FOR INTERMEDIATE PURIFICATION STEPS
Part of the Prochrom® line, the Prochrom®-Bio range stands up to its name, delivering the same level of quality. It is a robust low pressure chromatography technology, perfect for ensuring intermediate purification processing steps.
Achieve high purification quality and reproducibility thanks to our smart packing technology and get access to repacking-in-place to improve performance.
Secure timelines and process faster by operating at up to 5 bar allowing the use of innovative stationary phases which exhibit high back pressure.
Maintain and clean your column easily thanks to a clever top-down piston technology.
BioSC™: REDUCE YOUR INSULIN PRODUCTION COSTS
Several insulin analogs and formulations will go off patent in the coming years. The arrival of biosimilar insulins will greatly leverage the need to reduce production costs in order to remain competitive
Novasep proposes an innovative solution: BioSC™, a continuous chromatography technology.
The BioSC™ system enables:
- the reduction of resin and buffer consumption by up to 75%
- the increase of productivity by 2 to 4 fold
- a smaller footprint than batch chromatography for equivalent feed volumes
CUSTOMIZED TANGENTIAL FLOW FILTRATION
Tangential flow filtration is used for the production of insulin, at clarification, concentration and diafiltration steps. Novasep offers industrial, tailor-made TFF systems for 24/7 operations.