ADC payloads manufacturing

Axplora ADC payloads development and manufacturing

ADC payloads are usually complex structures produced through a 10-20 step synthesis process or by hemi synthesis. Manufacturing of HPAPI’s such as ADC payloads requires a contained and specially designed environment along the development & manufacturing process including R&D, analytical, production and storage.

With more than 15 years’ experience, Axplora is a world-leading commercial supplier of ADC payloads with a demonstrated track record of success in the synthesis and the purification of the main classes of payloads.

A world leader in ADC payloads manufacturing

Axplora is recognized in the development and commercial production of ADC payloads with a successful track-record of over 200 clinical and commercial cGMP batches produced.

  • Track record in the main classes of ADC payloads
    • Auristatins
    • Maytansines (DMx)
    • Pyrrolobenzodiazepines (PBD dimers)
    • Tecans
    • Customer proprietary payloads
  • High purity
    • Expertise in HPLC chromatography
    • Complex molecules purification
Axplora ADC payloads purification
Axplora ADC payloads purification
  • Safe handling of compounds with very low OEL
    • Equipped to handle highly potent compounds with OEL below 30 ng/m3/8hrs for R&D, small- & large-scale manufacturing and QC
  • Agile cGMP manufacturing
    • 30 g to >1 kg per batch
    • Pro-active & robust scale-up strategy to secure your supply chain in a cost-effective manner

To learn more about our expertise in ADC payloads manufacturing, discover our content:

Our ADC payloads manufacturing solutions

Axplora offers a full range of ADC payloads manufacturing services, from process development to cGMP production:

  • Development
    • Process & analytical transfer
    • Process & analytical development
    • Process characterization
    • Demonstration batch at 10-20g
  • Medium scale manufacturing
    • cGMP production for clinical trials
    • Process validation
    • cGMP production for commercial supply
    • Batch size: up to 500g
  • Large-scale manufacturing
    • cGMP production for clinical trials
    • Process validation
    • cGMP for commercial supply
    • Batch size: kilogram-scale
  • Quality Control
    • Method development, transfer and validation
    • IPC
    • Release testing
    • Stability studies
Axplora ADC payloads development and manufacturing
Axplora ADC payloads development and manufacturing

Our center of excellence for ADC payloads manufacturing

Located one hour from Paris by high-speed train, our Le Mans manufacturing site benefits from more than 30 years of experience in HPAPIs manufacturing and industrial chromatography. It has been successfully inspected by both the European authorities & the FDA recently.

Axplora Le Mans center of excellence for ADC payloads manufacturing

In addition to ADC payloads manufacturing, the site also offers bioconjugation services for ADCs to ensure chain simplification, timeline and cost optimization, and risk reduction.

This center of excellence for ADCs also allows a cross-functional collaborative approach between ADC experts, and a better project management with one global contract and quality agreement.

Our latest investments for ADCs

Our commitment to ADCs is embodied by our continued investments on our Le Mans site:

  • +23M€ invested over the last 10 years
Axplora ADC Quality control
Axplora ADC Quality control
Brochure CDMO services for ADCs cover