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Flow chemistry services

Novasep Flow Chemistry Services Banner

Flow chemistry is becoming increasingly important in API manufacturing, offering a number of advantages over traditional batch chemistry.

Flow chemistry has been identified by Novasep as a key area of innovation, complementary to existing batch manufacturing, that may open novel process windows by offering better solutions for challenging process steps.

Based on our strong experience in continuous processes and our dedicated team focused on flow chemistry development, we aim to become your preferred partner for flow chemistry development and manufacturing.

The benefits of flow chemistry

Improved process sustainability & cost-effectiveness

  • Decreased energy needs to cool/heat reactor
  • More linear scale-up, better reproducibility
  • Increased flexibility in batch size
  • Size equipment reduction

Access to innovative solutions for API manufacturing

  • Better control of unstable intermediates
  • Development and scale-up of photochemical processes
  • Production of highly energetic intermediates

Learn more about the benefits of flow chemistry in our poster:

Continuous Flow Chemistry Poster Thumbnail


A demonstrable expertise in flow chemistry

Strong experience in development

  • Dedicated team with more than 10 years experience of flow chemistry process development
  • Experience in different types of reactions (Cryogenic reactions, Photochemistry, Liquid-Gaz reactions, Liquid-Liquid reactions, …)
  • Specific development methodologies for flow processes (e.g. Process Modeling)

Novasep Flow Chemistry Expertise

Ability to offer flow solutions in Novasep’s core technologies

  • Hazardous chemistry and cryogenic chemistry are key technologies for Novasep, from process development to large scale manufacturing
  • Know-how and expertise to evaluate, compare and deliver the most efficient solution depending on the process requirements to best fit our customers’ needs
  • Strong engineering history for implementation of continuous processes


To learn more about our flow chemistry expertise, discover our content:

Type of content


Flow Chemistry: When to go with flow ?


Our flow chemistry services

Novasep offers a wide and flexible range of flow chemistry services, from lab-scale feasibility studies to validation:

Lab scale feasibility studies - Fast track

  • Evaluation of feasibility
  • Initial parameters evaluation
  • Recommendations for further process development

Process development / Optimization

  • Identification of the best process parameters using established methodologies
  • Selection of flow reactors best adapted to the reaction requirements
  • Estimation of production productivity and identification of best set-up

Novasep Flow Chemistry Process Optimization

Proof of Concept batch (non-GMP)

  • Production of 10’s gram of requested intermediate/API
  • Validation of productivity assumptions and product quality
  • Confirmation of process stability on longer run

Flexible cGMP pilot equipment

  • Pilot to small cGMP productions (up to 50 kg/week)
  • High modularity of the equipment giving access to a wide range of reaction conditions
  • Production of API and intermediates to support clinical studies


  • Process characterization (PAR & Fate and Purge studies)
  • Analytical method validations
  • Regulatory support


Our site experienced with flow chemistry

Our Chasse-sur-Rhône site offers a research platform in flow chemistry to develop methodologies for efficient process development under continuous flow conditions.

Novasep Chasse-sur-Rhone site

The site has recently benefited from a €6 million investment including the addition of
a cGMP pilot equipment for flow chemistry.

  • A full range of CDMO services for Pharmaceuticals
    A full range of CDMO services for Pharmaceuticals
    We provide flexible development and manufacturing solutions for small molecule APIs and advanced int...
  • Continuous flow chemistry poster‎ ‎
    Continuous flow chemistry poster‎ ‎

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