With our unique expertise in the development and production of pure enantiomers, we can scale up the chiral technology that best suits your molecule.
Asymmetric synthesis
We have extensive experience in stereoselective synthesis using both diastereoselective and enantioselective synthesis.
Our expertise and capacities in cryogenic reactions, organometallic catalysis and hydrogenation are clearly very strong assets to successfully conducting stereoselective reactions.
Chiral resolution by diastereomeric salt or complex formation
Resolution by diastereomeric salt or complex formation is probably the most common way to resolve racemic mixtures. It is based on the reaction of a racemate with an enantiomerically pure resolving agent.
This resolving agent can be an acid or a base if the racemate has a basic or acidic function or a neutral resolving agent for neutral species that will lead to a complex formation. The goal is therefore to find a resolving agent that preferentially binds one of the enantiomers of the molecule to afford a species less soluble in the solvent media than the non-desired enantiomer. Thus the salt or complex that is formed can be separated and converted back to the free acid, base, or neutral compound to lead to the pure desired enantiomer.
We combine our experience in designing and operating industrial chiral chromatography processes and technologies with our know-how in developing and scaling up challenging organic synthesis, to bring the most cost-efficient global chiral synthesis to reality.
At early development stage, you need methods to rapidly and securely prepare grams to kilograms of your candidates, ready for the next clinical phase. For these reasons, we can use supercritical fluid chromatography systems with our Prochrom® Supersep line. The SupersepTM technology is characterized by a high recycling rate of CO2, reducing production costs and making the process greener.
From early to late development stage, we can provide an extensive range of high-performance liquid chromatography systems (HPLC) with our Prochrom® range. HPLC is the most versatile chromatographic tool to perform chiral resolution with any racemic mixtures, even if they are highly polar or cytotoxic.
For late development and production, we propose the use of continuous chromatography Varicol® which is the most cost-effective, robust, and environmentally friendly route to produce your pure enantiomer at large-scale. Efficient and integrated solvent recycling translates into lower operational costs and minimizes solvent consumption.
To learn more about our full range of industrial chromatography services, download our dedicated leaflet:
