The purification of biomolecules, as well as natural products, requires a high degree of technical expertise and state-of-the-art technologies to deliver a robust and effective process leading to a high purity product.
Whether you’re struggling to purify your molecules, or do not have the capabilities to do so, Novasep can help you!
As a leading contract manufacturer for more than 30 years, we offer best-in-class purification services for molecules used as active ingredients for pharmaceutical or cosmetic products, whether of natural or synthetic origin, for your development, clinical and commercial needs.
Find out how Novasep can purify your biomolecules and natural extracts in our infographics!
A technical expertise in the purification of biomolecules and natural products
Recognized to bring the best to purification using key technologies, Novasep is well placed to address the challenges involved in the purification of your biomolecule:
Outstanding quality assurance track-record
- Facilities operating under full cGMP
- Our Pompey site has been successfully inspected by the ANSM in 2021
Recognized technical expertise
- More than 30 years as a leading supplier of CDMO purification services
- +10 years’ technical expertise in biomolecules purification
Experience from development to commercial
- Manufacturing of APIs using a wide range of purification technologies
- +25 purification process development projects managed each year
Wide range of purification solutions
- Whatever the source and the molecule type
Responsive & flexible approach
- Skilled team of experts
- Reactive to changes in customer needs and biomass variabilities
Purification of complex molecules
Use of state-of-the-art-equipment
Check out our content to learn more about our expertise:
| Type of content | Title |
|
Case study |
Serial Cleaners: purification services for natural extracts: Development and purification of a natural extract from clinical phase to routine commercial production |
|
Case study |
Serial Cleaners: purification services for animal extracts: Development and purification of a polyclonal antibody from a serum for clinical studies |
|
Case study |
Serial Cleaners: purification services for recombinants proteins: Development, cell culture, purification, formulation and Fill & Finish of a complex recombinant hydrophobic protein |
|
Article |
From Biomass to APIs: Chromatographic Purification of Natural Product Extracts |
Watch the video below to learn more about our technical expertise and to discover our Pompey site & our cutting-edge natural-based molecule CDMO purification services:
Know-how to purify a wide range of biomolecules
We can develop exclusive purification processes whatever the biomolecule type you work on:
- Blood derivative
- Enzyme
- Insulin
- Lipid
- Macrolide antibiotic
- Oligonucleotide
- Omega-3
- Peptide
- Recombinant peptide
- Synthetic peptide
- Plant-based extracts
- Alkaloids
- CBD
- Flavones
- Glycoside
- Saponins
- Taxanes, …
- Polysaccharide
- Protein
- Natural protein
- Recombinant Protein
- Rapalog
Our purification technologies
We have the know-how and the capacity to develop purification processes integrating multiple technologies including:
Chromatography (Low Pressure, Medium Pressure, High Pressure)
- Ion exchange chromatography
- Affinity chromatography
- Normal and reverse phase chromatography
- Chiral chromatography
Membrane filtration
- Nano filtration
- Micro and Ultra filtration
Auxiliary technologies
- Viral inactivation and viral clearance
- 0.2µm filtration (Bioburden reduction)
Watch the video below to discover a typical 5-step purification process, for natural extracts, to achieve your target purity levels:
Our solutions for your biomolecules purification
Novasep offers a full and flexible range of manufacturing services to develop and purify your biomolecules, from process development and analytical support to cGMP manufacturing.
Process development
- Feasibility studies & development
- Analytical transfer
- Process transfer & optimization
- DoE (Design of Experiments)
Scale-up
- Proof of Concept (PoC)
- cGMP & non GMP production
Manufacturing
- cGMP and non GMP production for clinical & commercial supply from grams to tons
- Process validation
- Analytical support
- Stability studies
Our dedicated site for the purification of your biomolecule
Our purpose-built manufacturing facility is located in Pompey (an hour and a half by high-speed train, east of Paris, France).
We also offer preparative chromatography services for the manufacture of small molecule APIs and intermediates.
