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Home / Process Solutions / Functional ingredients / Industrial processes / High-value proteins from whey and milk
Production of high-value proteins from whey and milk
Functional ingredients

Production of high-value proteins from whey and milk


Milk is composed of approximatively 26% protein on a dry matter basis, including very high-value proteins such as lactoferrin, alpha-lactalbumin, beta-lactoglobulin, and immunoglobulins. As experts in the production of dairy ingredients, we can help you produce high-value milk and whey derivatives.


Novasep offers process lines for the production of concentrated extracts of lactoferrin and lactoperoxidase (approx. 80% purity on a dry matter basis). The capture can be performed using our Applexion™ ion exchange technology with cationic resins: both the lactoferrin and lactoperoxidase are retained while the other components flow through. A selective elution is performed to recover and concentrate lactoferrin on the one hand and lactoperoxidase on the other hand, together with ions. The ionic load can then be reduced and the protein concentration increased by an ultrafiltration/nanofiltration step using organic filtration membranes.

Novasep Production Process Whey Proteins



Similarly, alpha-lactalbumin and beta-lactoglobulin can be captured directly from whey or from the flow-through during the cation exchange step by using an anionic exchanger. Proteins are then concentrated by ultrafiltration/nanofiltration.


The purity of these proteins can be significantly improved (>95%) by using our Prochrom®-Bio chromatography technologies.. In this case, adapted chromatographic media have to be selected. These very high-value products can be used for specific applications in pharma or clinical applications.


With the milk’s origin, the whey quality, and your target specifications having a significant impact on the purification process, we can help you design and choose the most adapted solution thanks to our experience in process development, from R&D to unit start-up.

Novasep Dairy Nanofiltration Reverse Osmosis

As experts in manufacturing processes for the dairy industry, we can also help you implement or improve your production of demineralized whey, lactose from edible to pharma grades and GOS for infant food formulation.

If you need to produce your first samples of whey or milk proteins under industrial conditions to evaluate the potential of your product, Novasep can also provide you with sample production services.

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