BioSC® continuous chromatography for biologics

The BioSC® is a groundbreaking low pressure continuous chromatography solution for the purification of monoclonal antibodies (mAbs), blood fractions and other biologics:

• Adaptability: operations from 1 column up to 6 columns in batch, parallel 
  batch, continuous chromatography or continuous process
• Easy switch from batch continuous, optimizing process parameters with BioSC® Predict software (Try for free the lite version in the download section)
• Reduction of resin and buffer by up to 75%
• Increased productivity by 2 to 6-fold

You want to know by how much it could improve your process?

Ask our experts for a simulation!

A Market in Continuous Evolution     

MAbs , insulin , blood fractionation , recombinant proteins , vaccines and viral vectors demand innovative technologies and bring new challenges:

• Continuous processes (perfusion …) and high titer feed (fed-batch) are more and more developed in USP. DSP is now becoming the bottleneck of biopharmaceutical processes.
• Large volumes of buffer and high priced media required, long process times, target protein degradation.
• Process intensification , flexibility of equipment, CAPEX reduction, smaller footprint.
• Time-to-market with lower costs at the same quality (biosimilars)
• Environmental challenges (buffer reduction, waste treatment…)
• High value blood proteins…

A precursor in continuous process improvement

For decades, Novasep has worked on continuous chromatography and has built the largest FDA-audited continuous chromatography platform at commercial scale. To adapt to the current biopharma challenges, Novasep is committed to delivering expertise in continuous chromatography, know-how by developing the state-of-the-art BioSC® Sequential Chromatography platform . 

BATCH	CONTINUOUS
Single column Each portion of the resin is working for a very short period of time	Multiple columns in series Media is used at its maximum capacity Target molecule is not lost Load more & faster

The only all-in-one tool on the market

Great power, small footprint!

Possibility to work with different process modes:

Batch Process	Parallel Batch	Continuous Chromatography from 2 to6 columns	Continuous Process

• Wide range of process scenario screening: Possibility to work from 1 to 6 columns or membrane to adapt all customer objectives (productivity, buffer and media savings…)
• Whatever your elution strategy (sequential, linear or step gradient) or your process strategy (mono or multi-resin), BioSC® allows you to develop or process in accordance with equipment specifications.

Predict your future!

BioSC® Predict is the unique simulation and optimization software for the development of continuous chromatography processes dedicated for the purification of biopharmaceuticals.

It is a process development accelerator enabling any scientist to start developing continuous chromatography processes even without prior knowledge.

With a few clicks, the user can switch from batch chromatography to an optimized continuous chromatography process, ready to be tested on the BioSC® Lab equipment.

Don't miss your chance to get your own copy of the BioSC® Predict Lite, available in a Lite version for you to test in the download section.

In addition to the standard chromatography sensors (pH, UV, conductivity), BioSC® also features extra sensors (flowmeter, pressure, temperature) for PAT approach.

21CFR Part 11 & GAMP 5 ready control software

BioSC® control software enables user-friendly, secure and traceable production compliant with FDA recommendations for PAT approach implementation:

• Multi-level access control
• Recipe editor
• Real-time monitoring of all process parameters

Upon request, the operating software can be connected to other databases or Distributed Control Systems (DCS) (Delta V).

Proven Continuous Scale-up

Whatever your scale, Novasep can provide the right continuous solution:

Fast and Continuous Global Support

• Capitalized on Novasep’s know-how to become an expert on Novasep technologies with our wide range of training offerings (equipment , process , maintenance, software).
• Through our process development team and experts, we have the possibility to develop, optimize and industrialize your valuable ideas and molecules.
• Stay up to date with our software upgrade services package.
• Maximize your up time by managing your OPEX with different levels of maintenance contracts.
• Based on your needs, you have the best of Novasep readily on your site, 24 hours a day, 7 days a week, to respond to any urgency.
• Try Novasep technologies with your molecule at site before adopting them with our rental offering.