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Home / Technologies / BioSC™ continuous chromatography for biologics

BioSC™ continuous chromatography for biologics

BioSC Lab web BioSC Pilot downstream bioprocess biologics

From lab to manufacturing, the BioSC™ chromatography systems enable batch and multiple multi-column processes (parallel batch, continuous chromatography/process) resulting in Process Intensification. The BioSC™ is a groundbreaking solution for the purification of monoclonal antibodies (mAbs), blood fractions and other biologics:

  • Adaptability: operations from 1 column up to 6 columns in batch, parallel batch, continuous chromatography or integrated process
  • Easy switch from batch to continuous, optimizing process parameters with BioSC™ Predict software
  • Reduction of resin and buffer by up to 75%
  • Increased productivity by 2 to 6-fold

You want to know by how much it could improve your process? Ask our experts for a simulation!

Depending on molecule properties (size, charge, hydrophobicity, biorecognition), our product ranges allow for several purification techniques:

  • Reverse Phase Chromatography (RP HPLC),
  • Normal Phase Chromatography (NP HPLC),
  • Hydrophobic Interaction Chromatography (HIC),
  • Ion Exchange Chromatography (Anion and Cation) (IEX),
  • Size Exclusion Chromatography (SEC),
  • Affinity Chromatography (AC).

 

Technology Evolution

A Market in Continuous Evolution

MAbs, insulin, blood fractionation, recombinant proteins, vaccines and viral vectors demand innovative technologies and bring new challenges:

  • Continuous processes (perfusion …) and high titer feed (fed-batch) are more and more developed in USP. DSP is now becoming the bottleneck of biopharmaceutical processes.
  • Large volumes of buffer and high priced media required, long process times, target protein degradation.
  • Process intensification, flexibility of equipment, CAPEX reduction, smaller footprint.
  • Time-to-market with lower costs at the same quality (biosimilars)
  • Environmental challenges (buffer reduction, waste treatment…)
  • High-value blood proteins…

 

A precursor in continuous process improvement

Novasep has worked on continuous chromatography and has built the largest FDA-audited continuous chromatography platform at commercial scale. To adapt to the current biopharma challenges, Novasep is committed to delivering expertise in continuous chromatography, know-how by developing the state-of-the-art BioSC™ Sequential Chromatography platform. 

Batch to continuous
BATCH CONTINUOUS
  • Single column
  • Each portion of the resin is working
    for a very short period of time

 

  • Multiple columns in series
  • Media is used at its maximum capacity
  • Target molecule is not lost
  • Load more & faster

 

The only all-in-one tool on the market

Great power, small footprint!

Possibility to work with different process modes:

Batch chromatography Parallel Batch Continuous chromatography   Continuous Process
Batch Process Parallel Batch,
Batch Multi-Column Chromatography 
Continuous Chromatography
from 2 to 6 columns,
Sequential Multi-Column Chromatography

Intensification of size exclusion

Isocratic Multi-Column Chromatography

Integrated Process,
Multi Steps Multi-Column Chromatography
  B-MCC S-MCC  I-MCC MS-MCC
  • Wide range of process scenario screening: Possibility to work from 1 to 6 columns or membrane to adapt all customer objectives (productivity, buffer and media savings…)
  • Whatever your elution strategy (sequential, linear or step gradient) or your process strategy (mono or multi-resin), BioSC™ allows you to develop or process in accordance with equipment specifications.

 

Predict your future!

BioSC™ Predict is the unique simulation and optimization software for the development of continuous chromatography processes dedicated to the purification of biopharmaceuticals.

It is a process development accelerator enabling any scientist to start developing continuous chromatography processes even without prior knowledge.

BioSC Predict

With a few clicks, the user can switch from batch chromatography to an optimized continuous chromatography process, ready to be tested on the BioSC™ Lab equipment.

Don't miss your chance to get your own copy of the BioSC™ Predict Lite, available in a Lite version for you.

 Download BioSC™ Predict

 

BioSC Control Software

In addition to the standard chromatography sensors (pH, UV, conductivity), BioSC™ also features extra sensors (flowmeter, pressure, temperature) for PAT approach. 

BioSC™ control software enables user-friendly, secure and traceable production compliant with FDA recommendations for PAT approach implementation:

  • Multi-level access control
  • Advanced recipe editor for multi-step approach
  • Real-time monitoring of all process parameters

Upon request, the operating software can be connected to other databases or Distributed Control Systems (DCS) (Delta V).

 

Proven Continuous Scale-up

Whatever your scale, Novasep can provide the right continuous solution:

  Lab Scale Pilot Industrial
Number of columns 1 to 6
Productivity Range (kg/day) <  0.01 0.1 Customized
Typical Column Diameter (mm) 5 to 16 25 to 200
Flow Rate Range (mL/min) 1-30 83 to 2500
Standard Max Operating Pressure (barg) 5 5
Dimensions WxHxD (cm) 69x90x63 200x200x100*
Weight (Kg) 120 300*

 *For a three modules configuration. 

Fast and Continuous Global Support

  • Capitalized on Novasep’s know-how to become an expert on Novasep technologies with our wide range of training offerings (equipment, process, maintenance, software).
  • Through our process development team and experts, we have the possibility to develop, optimize and industrialize your valuable ideas and molecules.
  • Stay up-to-date with our software upgrade services package.
  • Maximize your up-time by managing your OPEX with different levels of maintenance contracts.
  • Responsive support and hotline at your disposal.
  • Try Novasep technologies with your molecule at site before adopting them with our rental offering.

 

Related Documents

Brochure

Brochure Icon Insulin Purification Download

Application note

Brochure Icon Elemental packing, simplified packing operation without compromising your performance Download
Brochure Icon BioSC™ Pilot designed for effective and consistent chemical and microbiological cleaning Download

White paper

Brochure Icon Process Intensification and Continuous Bioprocessing by Novasep Download

Webinar

Video Chromatography intensification strategies using multi-column process Watch now
Video BioSC™ Pilot & BioSC™ Lab technologies Watch now
Video Turnkey solution for continuous downstream bioprocess Watch now
Video Control Strategy in a Continuous and Intensified Bioprocessing Watch now
Video Process development using simulation software for Multi-Column Chromatography Watch now
Downloads
  • Prochrom-Bio LPLC Columns
    Prochrom-Bio LPLC Columns
    Download +
  • BioSC™ Pilot
    BioSC™ Pilot
    BioSC™ Pilot, from chromatography skid to DSP skid for biologics
    Download +
  • BioSC™ System Product range
    BioSC™ System Product range
    Download +
  • Prochrom Hipersep-Bio LPLC skids
    Prochrom Hipersep-Bio LPLC skids
    Download +
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