The BioSC™ is a groundbreaking low pressure chromatography solution for the purification of monoclonal antibodies (mAbs), blood fractions and other biologics:
- Adaptability: operations from 1 column up to 6 columns in batch, parallel batch, continuous chromatography or integrated process
- Easy switch from batch to continuous, optimizing process parameters with BioSC® Predict software (Try for free the lite version)
- Reduction of resin and buffer by up to 75%
- Increased productivity by 2 to 6-fold
You want to know by how much it could improve your process?
Ask our experts for a simulation!
A Market in Continuous Evolution 
MAbs, insulin, blood fractionation, recombinant proteins, vaccines and viral vectors demand innovative technologies and bring new challenges:
- Continuous processes (perfusion …) and high titer feed (fed-batch) are more and more developed in USP. DSP is now becoming the bottleneck of biopharmaceutical processes.
- Large volumes of buffer and high priced media required, long process times, target protein degradation.
- Process intensification, flexibility of equipment, CAPEX reduction, smaller footprint.
- Time-to-market with lower costs at the same quality (biosimilars)
- Environmental challenges (buffer reduction, waste treatment…)
- High-value blood proteins…
A precursor in continuous process improvement
Novasep has worked on continuous chromatography and has built the largest FDA-audited continuous chromatography platform at commercial scale. To adapt to the current biopharma challenges, Novasep is committed to delivering expertise in continuous chromatography, know-how by developing the state-of-the-art BioSC™ Sequential Chromatography platform.
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BATCH | CONTINUOUS |
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The only all-in-one tool on the market
Great power, small footprint!
Possibility to work with different process modes:
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Batch Process | Parallel Batch, Batch Multi Columns Chromatography (B-MCC) |
Continuous Chromatography from 2 to 6 columns, Sequential Multi Columns Chromatography (S-MCC) |
Integrated Process, Multi Steps Multi Columns Chromatography (MS-MCC) |
- Wide range of process scenario screening: Possibility to work from 1 to 6 columns or membrane to adapt all customer objectives (productivity, buffer and media savings…)
- Whatever your elution strategy (sequential, linear or step gradient) or your process strategy (mono or multi-resin), BioSC™ allows you to develop or process in accordance with equipment specifications.
Predict your future!
BioSC™ Predict is the unique simulation and optimization software for the development of continuous chromatography processes dedicated to the purification of biopharmaceuticals.
It is a process development accelerator enabling any scientist to start developing continuous chromatography processes even without prior knowledge.
With a few clicks, the user can switch from batch chromatography to an optimized continuous chromatography process, ready to be tested on the BioSC™ Lab equipment.
Don't miss your chance to get your own copy of the BioSC™ Predict Lite, available in a Lite version for you to test in the download section.
In addition to the standard chromatography sensors (pH, UV, conductivity), BioSC™ also features extra sensors (flowmeter, pressure, temperature) for PAT approach.
BioSC™ control software enables user-friendly, secure and traceable production compliant with FDA recommendations for PAT approach implementation:
- Multi-level access control
- Advanced recipe editor for multi-step approach
- Real-time monitoring of all process parameters
Upon request, the operating software can be connected to other databases or Distributed Control Systems (DCS) (Delta V).
Proven Continuous Scale-up
Whatever your scale, Novasep can provide the right continuous solution:
Lab Scale | Pilot | Industrial | |
Number of columns | 1 to 6 | ||
Productivity Range (kg/day) | < 0.01 | 0.1 | Customized |
Typical Column Diameter (mm) | 5 to 16 | 25 to 200 | |
Flow Rate Range (mL/min) | 1-30 | 83 to 2500 | |
Standard Max Operating Pressure (barg) | 5 | 5 | |
Dimensions WxHxD (cm) | 69x90x63 | 200x200x100* | |
Weight (Kg) | 120 | 300* |
*For a three modules configuration.
Fast and Continuous Global Support
- Capitalized on Novasep’s know-how to become an expert on Novasep technologies with our wide range of training offerings (equipment, process, maintenance, software).
- Through our process development team and experts, we have the possibility to develop, optimize and industrialize your valuable ideas and molecules.
- Stay up-to-date with our software upgrade services package.
- Maximize your up-time by managing your OPEX with different levels of maintenance contracts.
- Responsive support and hotline at your disposal.
- Try Novasep technologies with your molecule at site before adopting them with our rental offering.