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Home / Technologies / Hazardous chemistry / Hazardous chemistry: Carbonylation with carbon monoxide

Hazardous chemistry: Carbonylation with carbon monoxide

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We use gaseous carbon monoxide (at up to 10 bar) in palladium-catalyzed reactions for the carbonylation of aryl halides to produce esters, amides, ketones or aldehydes at hundred kilo scale per batch.

 Novasep CMO Carbonylation

The use of carbon monoxide for the carbonylation of aryl halides in aryl esters is a shortcut route compared to a standard 3-step synthesis via a Grignard reagent formation. In addition, carbonylation is a much more versatile than organomagnesium chemistry since it is much more permissive in terms of functional groups.

Novasep CMO Alkoxycarbonylation

Carbonylation with carbon monoxide can be handled by our Leverkusen site, located in Germany.

Novasep Manufacturing Facility For Hazardous Chemistry In Leverkusen

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Novasep Hazardous Chemistry Leaflet

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    A full range of hazardous chemistry services for APIs
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